Holger Lerche Selected Research

Syntaxin 1

12/2019	Clinical spectrum of STX1B-related epileptic disorders.
12/2017	Motor cortex excitability in seizure-free STX1B mutation carriers with a history of epilepsy and febrile seizures.
12/2014	Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes.

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Holger Lerche Research Topics

Disease

55	Epilepsy (Aura) 10/2022 - 04/2003
22	Seizures (Absence Seizure) 03/2022 - 04/2003
13	Epileptic Syndromes 12/2019 - 01/2005
11	Generalized Epilepsy 01/2020 - 04/2003
11	Idiopathic Generalized Epilepsy 09/2015 - 04/2003
9	Juvenile Myoclonic Epilepsy 09/2019 - 04/2003
8	Partial Epilepsies (Epilepsy, Partial) 01/2022 - 04/2008
8	Brain Diseases (Brain Disorder) 01/2020 - 09/2013
8	Absence Epilepsy (Childhood Absence Epilepsy) 11/2017 - 04/2003
6	Ataxia (Dyssynergia) 07/2022 - 10/2014
5	Intellectual Disability (Idiocy) 07/2022 - 02/2009
5	Febrile Seizures (Febrile Seizure) 12/2019 - 02/2013
4	Status Epilepticus (Complex Partial Status Epilepticus) 12/2019 - 01/2012
4	Myoclonic Epilepsies (Myoclonic Encephalopathy) 05/2017 - 03/2009
3	Drug-Related Side Effects and Adverse Reactions 01/2022 - 01/2008
3	Neurodevelopmental Disorders 01/2022 - 05/2017
3	Drug Resistant Epilepsy 12/2019 - 08/2011
3	Autistic Disorder (Autism) 12/2019 - 02/2009
3	Cognitive Dysfunction 12/2017 - 11/2013
3	Hippocampal Sclerosis 10/2017 - 10/2013
3	Temporal Lobe Epilepsy 10/2017 - 10/2013
3	Fever (Fevers) 05/2017 - 11/2013
3	Convulsions benign familial neonatal dominant form 09/2016 - 10/2011
3	Nervous System Diseases (Neurological Disorders) 10/2014 - 04/2003
3	Dyskinesias (Dyskinesia) 10/2014 - 06/2008
3	Migraine Disorders (Migraine) 10/2013 - 06/2008
2	Limbic Encephalitis (Paraneoplastic Limbic Encephalitis) 03/2022 - 02/2013
2	Movement Disorders (Movement Disorder) 01/2022 - 01/2021
2	Channelopathies 01/2020 - 01/2010
2	Hypokalemic Periodic Paralysis (Periodic Paralysis, Hypokalemic) 07/2019 - 04/2002
2	Paralysis (Palsy) 07/2019 - 04/2002
2	Neoplasms (Cancer) 01/2019 - 04/2003
2	Stroke (Strokes) 01/2019 - 09/2013
2	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 01/2019 - 07/2013
2	Multiple Sclerosis 11/2016 - 11/2013
2	Rolandic Epilepsy (Centrotemporal Epilepsy) 09/2015 - 06/2015
2	Inborn Genetic Diseases (Disease, Hereditary) 07/2014 - 07/2010
2	Benign Neonatal Epilepsy (Benign Familial Neonatal Convulsions) 01/2014 - 09/2013
2	Deafness (Deaf Mutism) 07/2013 - 07/2010
1	Genetic Predisposition to Disease (Genetic Predisposition) 03/2022
1	Stiff-Person Syndrome (Stiff Man Syndrome) 03/2022
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 03/2022
1	Neuroblastoma 01/2022
1	Muscle Weakness 04/2021
1	Glycogen Storage Disease Type II (Pompe's Disease) 04/2021
1	Episodic Ataxia 01/2021
1	Neurologic Manifestations (Neurological Manifestations) 12/2019

Drug/Important Bio-Agent (IBA)

19	Anticonvulsants (Antiepileptic Drugs)IBA 09/2020 - 10/2006
14	Immunoglobulin E (IgE)IBA 11/2017 - 04/2003
11	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2010
7	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 07/2022 - 07/2010
7	Ion Channels (Ion Channel)IBA 01/2021 - 01/2005
7	Pharmaceutical PreparationsIBA 01/2021 - 10/2013
6	Sodium Channels (Sodium Channel)IBA 01/2020 - 04/2002
5	Potassium Channels (Potassium Channel)IBA 01/2020 - 09/2013
5	ezogabine (retigabine)IBA 08/2015 - 04/2008
4	Sodium Channel BlockersIBA 01/2022 - 05/2017
4	Carbamazepine (Tegretol)FDA LinkGeneric 01/2021 - 08/2015
4	PotassiumIBA 01/2020 - 07/2010
4	SodiumIBA 07/2019 - 11/2016
3	Levetiracetam (Keppra)FDA LinkGeneric 01/2022 - 11/2012
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 04/2014
3	Biological ProductsIBA 01/2020 - 10/2013
3	Voltage-Gated Sodium ChannelsIBA 12/2019 - 11/2016
3	Valproic Acid (Depakote)FDA LinkGeneric 12/2019 - 08/2015
3	Syntaxin 1IBA 12/2019 - 12/2014
3	Phosphotransferases (Kinase)IBA 01/2019 - 04/2012
3	Glucose (Dextrose)FDA LinkGeneric 12/2018 - 06/2008
3	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 08/2015 - 07/2008
3	Ligand-Gated Ion ChannelsIBA 02/2013 - 01/2005
3	CationsIBA 02/2013 - 01/2008
3	Chloride Channels (Chloride Channel)IBA 09/2009 - 04/2003
2	HLA Antigens (Human Leukocyte Antigens)IBA 03/2022 - 01/2018
2	AutoantibodiesIBA 03/2022 - 02/2013
2	gamma-Aminobutyric Acid (GABA)IBA 01/2022 - 04/2007
2	Oxcarbazepine (Trileptal)FDA LinkGeneric 03/2019 - 08/2015
2	Lamotrigine (Lamictal)FDA LinkGeneric 08/2015 - 11/2012
2	Glucose Transporter Type 1IBA 08/2015 - 10/2014
2	Nonsense Codon (Nonsense Mutation)IBA 09/2013 - 01/2013
1	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 03/2022
1	Protein Isoforms (Isoforms)IBA 03/2022
1	Tetrodotoxin (Tetradotoxin)IBA 01/2022
1	AcidsIBA 04/2021
1	GlucosidasesIBA 04/2021
1	EnzymesIBA 04/2021
1	Riluzole FDA LinkGeneric 01/2021
1	brivaracetamIBA 09/2020
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2020
1	Lacosamide FDA Link 12/2019
1	FenfluramineIBA 12/2019
1	sec-butyl-propylacetamideIBA 12/2019
1	valnoctamideIBA 12/2019
1	P-2 (P 2)IBA 11/2019
1	PlasticsIBA 08/2019

Therapy/Procedure

17	Therapeutics 10/2022 - 08/2011
3	Precision Medicine 10/2022 - 10/2021
3	Ketogenic Diet 08/2015 - 09/2009
2	Electrodes (Electrode) 04/2021 - 01/2018
2	Drug Therapy (Chemotherapy) 09/2008 - 10/2006
1	Deep Brain Stimulation 01/2020